Aminoglycoside‐Hybrid Ligands Targeting the Ribosomal Decoding Site

Abstract

Bacterial bridges: RNA helix 44 within the small subunit of the bacterial ribosome is the target for natural aminoglycoside antibiotics of the neomycin and hygromycin classes, which bind at neighboring sites and thereby interfere with protein synthesis. We describe synthetic aminoglycoside-hybrid ligands, such as 1, designed to inhibit translation by bridging between the neamine and hygromycin binding sites.