Immunohistochemistry as a screening tool for<i>ALK</i>rearrangement in NSCLC: evaluation of five different ALK antibody clones and<i>ALK</i>FISH

Abstract

D5F3 with OptiView exclusively stained rearranged cases with strong intensity, without a single false-positive or false-negative case. The number of subsequent ALK FISH analyses required would have decreased from 303 to 14 cases (-95.4%), reducing significantly the time, work and costs without any loss of diagnostic quality and accuracy.