Concepedia

Safety and Efficacy of a Soluble P75 Tumor Necrosis Factor Receptor (Enbrel, Etanercept) in Patients With Advanced Heart Failure

Anita Deswal, Biykem Bozkurt, Yukihiro Seta, Semahat Parilti-Eiswirth, F. Ann Hayes, Consuelo Blosch, Douglas L. Mann

Circulation · 1999 · 396 citations · 5 references

DOI

Abstract

A single intravenous infusion of etanercept was safe and well tolerated in patients with NYHA class III heart failure. These studies provide provisional evidence that suggests that etanercept is sufficient to lower levels of biologically active TNF and may lead to improvement in the functional status of patients with heart failure.

References

5

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

Larry W. Moreland, Scott W. Baumgartner, Michael Schiff et al. · New England Journal of Medicine · 1997 · 1.6K citations · Full text

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Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

Guillermo Torre‐Amione, Samir Kapadia, Claude R. Benedict et al. · Journal of the American College of Cardiology · 1996 · 1.2K citations

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Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

Toru Kubota, Charles F. McTiernan, Carole S. Frye et al. · Circulation Research · 1997 · 822 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

Biykem Bozkurt, Scott B. Kribbs, Fred J. Clubb et al. · Circulation · 1998 · 815 citations · Full text

Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathy

Karen Sliwa, Daniel Skudicky, Geoffrey Candy et al. · The Lancet · 1998 · 216 citations

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