Cytotoxic and Antifungal Diterpenes from the Seeds of<i>Alpinia galanga</i>

Abstract

Two new skeletal diterpenes, named galanal A and B, and two new labdane-type diterpenes, named galanolactone and ( E )-8 (17),12-labddiene-15,16-dial, were isolated from Alpinia galanga (Zingiberaceae) together with ( E )-8β(17)-epoxylabd-12-ene-15,16-dial. Their structures were established on the basis of spectral and chemical evidence. The cytotoxic and antifungal activities of these compounds are discussed.