Chemistry of Acronycine; Part 1. Synthesis of 1-Hydroxy-1,2-dihydroacronycine and 2-Hydroxy-1,2-dihydroacronycine

Abstract

The synthesis of the potential acronycine prodrugs, 1-hydroxy-1,2-dihydroacronycine ( 2) and 2-hydroxy-1,2-dihydroacronycine ( 3) are described using the natural alkaloid acronycine ( 1) as starting material.