Journal of Oral Science · 2009 · 132 citations · 14 references
DentistryOral Health SciencesOral MedicineAntimicrobial PharmacologyAntimicrobial PharmacotherapyOral MicrobiologyAntifungal AgentsAntifungal TherapyOral CandidiasisOral Fungal InfectionsOral Fungal MicrobiologyOral Microbial PathogenesisCandida Albicans InfectionFungal Oral InfectionsMinimum Inhibitory Concentration DeterminationMinimum Toxic ConcentrationNew Antifungal AgentsOral Antifungal AgentsOral Antifungal TherapyTreatment Of Oral Candidiasis
This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 microg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alpha-mangostin was determined and it was found that alpha-mangostin at 4,000 microg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis.
14
Antifungal activities of origanum oil against Candida albicans
Vijaya Manohar, Cass Ingram, Judy Gray et al. · Molecular and Cellular Biochemistry · 2001 · 240 citations