Chemical Communications · 2012 · 53 citations · 24 references
PharmacyMedicinal ChemistryMolecular BiologyCancer PharmacologyDrug DesignOrganometallic ChemistryG-quadruplex ChemistryLigand BindingTelomere BiochemistryTelomere BiologyAnticancer ActivityBinding ConstantsG-quadruplexesSelectivityTelomerase InhibitorsTelomerase RegulationTelomere-telomerase InteractionsTelomeric Repeats
Two new Pt(II) squares with quinoxaline-bridges selectively stabilize human telomeric G-quadruplexes with high binding constants (10(7)-10(9) M(-1)) and an unprecedented binding stoichiometric ratio of Pt(II) square/G-quadruplex (6 : 1). This selectivity is likely due to the Pt(II) squares' cube-like shape. Both Pt(II) squares also show significant telomerase inhibition and anticancer efficacy.
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science · 1994 · 7.1K citations
Inhibition of telomerase by G-quartet DMA structures
Alan M. Zahler, James R. Williamson, Thomas R. Cech et al. · Nature · 1991 · 1.1K citations
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Sunita Kumari, Anthony Bugaut, J Huppert et al. · Nature Chemical Biology · 2007 · 822 citations · Full text