Role of a Paracrine Action of Mesenchymal Stem Cells in the Improvement of Left Ventricular Function After Coronary Artery Occlusion in Rats

Abstract

Fresh medium, conditioned medium and MSC injection all improved LV function at 4 weeks after treatment compared with saline treatment in a rat myocardial infarct model; only MSCs increased wall thickness. Since the culture medium contains nutrients and bovine serum, the roles of the soluble factors released by MSCs might be masked. The effect of these nutrients needs further investigation.