Drug Development and Industrial Pharmacy · 2003 · 14 citations · 20 references
Natural SciencesBiochemistryBioengineeringBiomaterialsPolymer ChemistryPolymer EngineeringBiodegradable BiomaterialsBiodegradable PolymersBiodegradationBiomaterial DegradationPolymer DegradationPolymeric BiomaterialsBiodegradation MechanismsBuffer SolutionsEnzymatic DegradationHydrolytic Degradation StudiesPh DependencePh-dependent DegradationPolymer BiodegradationPolymer Degradation Mechanisms
This study was designed to investigate two rosin-based polymers (R-1 and R-2) for their in vitro and in vivo biodegradation behavior. The in vitro hydrolytic degradation was carried out in buffer solutions of pH 4.4, 7.4, and 10.4 at 37 degrees C. Enzymatic degradation was studied using enzymes lipase, pancreatine, and pectinase. Free films of the two polymers were subcutaneously implanted in rabbits for the in vivo biodegradation. The extent of degradation was determined quantitatively by weight loss and was followed qualitatively by scanning electron microscopy. The extent and the rate of degradation was better in vivo than in vitro. The polymers showed poor enzymatic degradation and a highly pH-dependent hydrolytic degradation.
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