NITRIC OXIDE DONATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS INDUCE APOPTOSIS IN HUMAN PROSTATE CANCER CELL SYSTEMS AND HUMAN PROSTATIC STROMA VIA CASPASE-3

Abstract

NO-NSAIDs are potent antiproliferative pro-apoptotic compounds in prostate cell systems. This pro-apoptotic effect is mediated via caspase-3 and it is independent of the type of prostate cell used. These findings have ramifications for the use of these new drugs in prostate cancer chemoprevention or treatment.