The Isolation and Structure of Ervaticine, a New Indole Alkaloid from Ervatamia coronaria

Abstract

A new 2-acylindole alkaloid "ervaticine" was isolated from t h e leaves of Ervatamia coronaria and i t s s t r u c t u r e was determined a s ( I ) on t h e basis of spectral s t u d i e s .Ervatamia coronaria Stapf (Apocynaceae) is a glabrous, e v e r g r e e n t r e e found a b u n d a n t l y in the g a r d e n s of West Pakistan.T h e plant i s used in the indigenous system of medicine f o r the treatment of apthalmia, for application a n wounds a n d inflsmmed p a r t s of t h e body, a s anthelmintic, 1 e t c .Anticancer activity has been shown b y t h e c r u d e e x t r a c t s of the plant .A number of 2-6 indole alkaloids have previously been reported b y u s from i t s leaves