The Preparation and Antifungal Activity of Some Salicylic Acid Derivatives

Abstract

Abstract A series of 2-alkoxy derivatives of benzamide, halogenated benzamides, 3-naphthamide, and N-substituted benzamides has been prepared and tested in vitro as potential antifungal agents. 2-n-Amyloxybenzamide, the most active of the derivatives studied, is a slow-acting fungicide of greater fungistatic potency than undecylenic acid, N-n-butyl-3-phenyl-salicylamide, salicylanilide, Nystatin, phenylmercuric acetate, sodium ethylmercurithiosalicylate and 8-hydroxyquinoline.