Experimental Biology and Medicine · 1961 · 26 citations · 0 references
Life SciencesBiologyInfectious DiseasesImmunopathologyMolecular VirologyVirologyAnimal VirusesHost-virus InteractionsOncogenic VirusesViral InfectionsViral PathogenesisViral PathologyAnimal Viral PathogenesisExperimental Animal Models Of Viral InfectionHistologic ExaminationHost Cell TropismMurine Models
The murine host range of Friend leukemia virus has been investigated quantitatively. Virus failed to multiply in C57BL and A strains. About 70% of C3H mice were susceptible, but overt disease developed in only 39%, the remainder being detectable by histologic examination only. Virus multiplied more slowly and to a lesser degree in C3H mice than in Swiss, DBA/2 and BALB/c, which were highly susceptible. Splenomegaly was more marked and more regular in BALB/c than in any of the other strains investigated; 100% of these mice being susceptible after initial adaptation.