Journal of the American Medical Association · 1959 · 34 citations · 1 references
PharmacyInfectious DiseasesPharmacotherapyAntimicrobial PharmacotherapyAntimicrobial ResistanceInfectious Disease PharmacotherapyAntibiotic ResistanceBacterial InfectionsMultidrug ResistanceSexually Transmitted Infection PharmacotherapyAntibiotic Therapy For GonorrheaAntimicrobial Resistance In GonorrheaMultiple Daily InjectionsNeisseria Gonorrhoeae Resistance
The results of treating patients with acute gonorrhea by five daily intramuscular injections of 600,000 units of procaine penicillin G were followed up in 148 men. The treatment failed in 30. In 13 of these a second course was given. It was successful in nine, and in the four cases of failure cure was obtained with oxytetracycline. In 17 men the initial course of penicillin which failed was followed by treatment with oxytetracycline; this was successful in 15 cases, and in the 2 men who were not cured by it treatment with chloramphenicol was successful. Two cases of failure of penicillin are cited to illustrate the course of the infection. The present high rate of failure with repeated doses is in marked contrast to the much lower rate of failure with single smaller doses reported elsewhere two years ago. This evidence that a penicillin-resistant strain of Neisseria gonorrhoeae has emerged is of grave significance.
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