Brom-ergocryptine in the Treatment of Phenothiazine-Induced Galactorrhoea

Abstract

An ergot alkaloid, 2-br-alpha-ergocryptine (CB 154), referred to hereafter as brom-ergocryptine, has been reported to inhibit puerperal lactation (Varga, Lutterbeck et al. , 1972), and to terminate breast secretion in patients with inappropriate lactation (Lutterbeck, Pryor et al. , 1971). Besser, Park et al. (1972) found that the drug suppressed elevated levels of plasma prolactin in five patients whose inappropriate lactation was due to a variety of causes. This hormonal effect was accompanied by clinical changes such as the disappearance of galactorrhoea, return of menstruation, and an increase in sexual potency.