TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study

Abstract

The majority of levothyroxine-treated women have early gestational TSH levels above the recommended targets (>2.5 mU/L) with a strong risk of miscarriage at levels exceeding 4.5 mU/L. There is an urgent need to improve the adequacy of thyroid hormone replacement in early pregnancy.