Role of the Thymus in Transplantation Tolerance in Miniature Swine: V. Deficiency of the Graft-to-Thymus Pathway of Tolerance Induction in Recipients of Cardiac Transplants

Abstract

The graft-to-thymus pathway that plays an important role in tolerance induction to renal allografts appears to be relatively deficient in recipients of cardiac grafts. Strategies to increase donor antigen migration to the host thymus might therefore assist in tolerance induction to cardiac allografts.