Menstrual irregularity and bone mass in premenopausal women: Cross-sectional associations with testosterone and SHBG

Abstract

Irregular menstrual cycles were associated with higher bone mass in this population-based sample of premenopausal women suggesting menstrual disturbance should continue to be evaluated but may be less harmful for bone mass. The association between menstrual irregularity and bone mass was partially mediated by markers of androgen status especially free testosterone.