Cocrystallization of C-butyl pyrogallol[4]arene and C-propan-3-ol pyrogallol[4]arene with gabapentin

Abstract

The single crystal X-ray diffraction structures for three cocrystals of C-butyl pyrogallol[4]arene and C-propan-3-ol pyrogallol[4]arene with the pharmaceutical gabapentin are described. The variation of solvent conditions and functionalities of the pyrogallol[4]arene tails demonstrates how these calixarene-like molecules can be used in the design of cocrystals with target molecules.