Ketamine spares morphine consumption after transthoracic lung and heart surgery without adverse hemodynamic effects☆

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

John H. Krystal · Archives of General Psychiatry · 1994 · 3.3K citations

Medicine, Neuroscience, Pharmacology +13

NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

Anil K. Malhotra · Neuropsychopharmacology · 1996 · 695 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery

Audun Stubhaug, Harald Breivik, Per Kristian Eide et al. · Acta Anaesthesiologica Scandinavica · 1997 · 516 citations

Nursing, Anesthesiology, Surgery +17

The prevalence of chronic chest and leg pain following cardiac surgery: a historical cohort study

Julie Bruce, Nigel E Drury, Amudha Poobalan et al. · Pain · 2003 · 346 citations

Medicine, Surgery, Cardiothoracic Surgery +11

The Role of Ketamine in Preventing Fentanyl-Induced Hyperalgesia and Subsequent Acute Morphine Tolerance

Jean‐Paul Laulin, P. Maurette, Jean‐Benoît Corcuff et al. · Anesthesia & Analgesia · 2002 · 344 citations

Medicine, Pharmacology, Pharmacotherapy +17