Sexually Transmitted Infections · 1985 · 17 citations · 17 references
PharmacyInfectious DiseasesPharmacotherapyAntimicrobial PharmacologyAntimicrobial PharmacotherapyMedical MicrobiologyAntibiotic ProphylaxisSexually Transmitted Infection CareSexually Transmitted Infection PharmacotherapySexually Transmitted InfectionsUrinary Tract Infection PharmacotherapyUrinary Tract InfectionsAntibiotic Therapy For GonorrheaAntimicrobial Resistance In GonorrheaBeta-lactamase InhibitorsCeftriaxone TherapyIntramuscular Injection TechniqueProphylactic Antibiotic Therapy
From 26 April to 30 June 1983 a total of 200 men with uncomplicated gonococcal urethritis were randomly treated with either 2 g spectinomycin or 250 mg ceftriaxone, both administered intramuscularly. Of 197 isolates tested for the presence of the enzyme beta lactamase, 91 (46.2%) were positive (PPNG) and 106 (53.8%) were non-PPNG strains. All 93 patients treated with spectinomycin and followed up and 97 treated with ceftriaxone and followed up were cured. Ceftriaxone 250 mg administered by intramuscular injection is highly effective in treating gonococcal infections caused by both PPNG and non-PPNG strains and is an appropriate alternative to spectinomycin.
17
Pharmacokinetics of ceftriaxone in humans
Indravadan H. Patel, S Chen, Mia Parsonnet et al. · Antimicrobial Agents and Chemotherapy · 1981 · 241 citations · Full text
National Gonorrhea Therapy Monitoring Study
Harold W. Jaffe, James W. Biddle, Clyde Thornsberry et al. · New England Journal of Medicine · 1976 · 162 citations