Stroke Volume and Peripheral Resistance during Infusion of Isoproterenol at a Constant Fixed Heart Rate

Abstract

THE hemodynamic effects of isoproterenol have been described in the literature in a variety of clinical1-2 and experimental conditions.13-16 In these reports, the action of this drug on the heart rate and stroke volume has been emphasized. However, no attempt has been made to study its hemodynamic conse- quences in man when the heart rate is maintained constant throughout the experiment. Under this circumstance it is possible to separate the peripheral from the central effects of this drug on the circulation.