The Annals of Statistics · 1980 · 13 citations · 0 references
Public HealthPharmacotherapyExperimental DesignClinical Trial DesignClinical TrialsRandomized Comparative TrialsSequential ExperimentationSequential TestingTrial Sequential AnalysisBinomial ExpressionsOperating Characteristics EvaluationSample Size CalculationSample Size EstimationSequential Clinical Trial DesignSequential DesignSequential P-valuesSequential Probability Ratio Testing
Sequential designs are proposed for clinical trials to compare two binomial success probabilities, $p_1$ and $p_2$. Approximations to the operating characteristics and expected sample size are obtained and compared with simulations. Special reference is made to the problem of comparing vasopressin and placebo for stopping upper gastrointestinal hemorrhage.