A Simple Synthesis of Furo[3′,4′:5,6]pyrido[2,3‐<i>d</i>]pyrimidine Derivatives through Multicomponent Reactions in Water

Abstract

Abstract A series of furo[3′,4′:5,6]pyrido[2,3‐ d ]pyrimidine and indeno[2′,1′:5,6]pyrido[2,3‐ d ]pyrimidine derivatives were synthesized by three‐component reactions involving an aldehyde, 2,6‐diaminopyrimidine‐4(3 H )‐one, and either tetronic acid or indane‐1,3‐dione in water, under microwave irradiation and traditional heating conditions, without use of any catalyst. This protocol has the advantages of higher yields, lower cost, reduced environmental impact, and convenience of procedure. The synthesis of a class of important compounds in aqueous medium has been achieved. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2007)