Age and Severity of Mucosal Lesions Influence the Performance of Serologic Markers in <i>Helicobacter pylori</i>–Associated Gastroduodenal Pathologies

Abstract

This study shows that H. pylori infection and CagA are risk markers for intestinal metaplasia. The prevalence of these risk markers decreases in gastric cancer, probably reflecting that infection decreases after advanced atrophy and metaplasia in the gastric mucosa. State of the disease, age, and sex influence the association of H. pylori infection and IgG response to CagA with gastroduodenal diseases.