Human Macroprolactin Displays Low Biological Activity via Its Homologous Receptor in a New Sensitive Bioassay

Abstract

Whereas both bioassays achieve similar results with respect to monomeric PRL activity, our results indicate that the activity displayed by bbPRL toward the rat receptor may be inappropriate because it is not observed in the human PRLR-mediated assay, consistent with the apparent absence of bioactivity in vivo.