Phosphine-catalyzed asymmetric [4+1] annulation of Morita–Baylis–Hillman carbonates with dicyano-2-methylenebut-3-enoates

Abstract

A novel asymmetric [4+1] annulation of MBH carbonates with dicyano-2-methylenebut-3-enoates has been developed for the first time, providing an efficient and enantioselective synthesis of highly functionalized cyclopentenes bearing one all-carbon quaternary stereogenic center.