G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

Carlos Bais, Bianca Santomasso, Omar A. Coso et al. · Nature · 1998 · 838 citations

Molecular Virology, Medicine, Viral Pathogenesis +9

Proton-sensing G-protein-coupled receptors

Marie‐Gabrielle Ludwig, M. Vanek, Danilo Guerini et al. · Nature · 2003 · 726 citations

Signal Transduction, Biochemistry, G Protein-coupled Receptor +5

Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation

David Julius, Thomas J. Livelli, Thomas M. Jessell et al. · Science · 1989 · 356 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

Lee F. Allen, R J Lefkowitz, M G Caron et al. · Proceedings of the National Academy of Sciences · 1991 · 320 citations · Full text

Genetics, Receptor Gene, Cellular Physiology +16