Expression of β‐defensin‐4 in “an in vivo and ex vivo model” of human osteoarthritic knee meniscus

Abstract

The present study suggests an activation of β-defensin-4 induction, in human knee meniscus induced by the OA inflammatory process. It may represent an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling in OA articular joints. In conclusion, the present paper suggests the clinical relevance of β-defensin-4 in the prospective of future alternative medical treatment for OA.