Retinoid Hyperostosis

Abstract

An oral synthetic vitamin A derivative, 13-cis-retinoic acid (isotretinoin), is effective in controlling a wide variety of dermatoses. Short-term use produces sustained remission in severe refractory cystic and conglobate acne.1 Higher doses and long-term administration are required to control keratinizing dermatoses, such as lamellar ichthyosis.2 In four of nine consecutive patients receiving long-term 13-cis-retinoic acid for ichthyosis, we have observed an ossification disorder resembling diffuse idiopathic skeletal hyperostosis.Case 1Two years after beginning to take 13-cis-retinoic acid (3 mg per kilogram of body weight per day) for lamellar ichthyosis, a 33-year-old woman had . . .