Journal of General Microbiology · 1977 · 19 citations · 9 references
Life SciencesMicrobiologyMolecular BiologyDna RepairDna ReplicationMicrobial GeneticsDna CrosslinkingDna DamageDna Damage SignalingDna Double-strand Break RepairGenotoxic CarcinogenesisGenotoxicity MechanismsDna Damage InductionDna Replication InhibitorsDna Synthesis InhibitionDrug-induced Dna DamageEscherichia ColiUltraviolet MutagenesisUltraviolet-induced Dna DamageUv-induced Dna Lesions
The antimicrobial drug 1-methyl-2-nitro-5-vinylimidazole (MEV) preferentially blocked DNA synthesis, was mutagenic and induced coliphage lambda in Escherichia coli. The antibacterial effects of MEV are the consequences of repairable damage to DNA, as shown by hypersensitivity of recA and uvr strains to MEV and related drugs, stimulation by MEV of DNA turnover which was dependent on the product of the uvrA gene, and the presence of cross-links in DNA from MEV-treated bacteria.
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