Concepedia

Detection by 32P-postlabelling of 8-oxo-7,8-dihydro-2′-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver

Imed Maatouk, Noureddine Bouaı̈cha, Marie José Plessis, François Périn

Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2004 · 61 citations · 36 references

DOI

Concepts

References

36

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Keith C. Cheng, D S Cahill, Hiroshi Kasai et al. · Journal of Biological Chemistry · 1992 · 1.8K citations · Full text

, , +17

Liver Failure and Death after Exposure to Microcystins at a Hemodialysis Center in Brazil

Elise M. Jochimsen, Wayne W. Carmichael, Jisi An et al. · New England Journal of Medicine · 1998 · 1.1K citations · Full text

, , +14

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

Hiroshi Kasai, Susumu Nishimura · Nucleic Acids Research · 1984 · 943 citations · Full text

, , +11

Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay

Yoshio Ueno, Satoshi Nagata, Tomoaki Tsutsumi et al. · Carcinogenesis · 1996 · 750 citations · Full text

, , +17

Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication

Stephan Pflugmacher, Claudia Wiegand, Axel Oberemm et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 1998 · 552 citations

, , +16