Effects of Tryptophan Depletion on Cognitive Functioning, Obsessive-Compulsive Symptoms and Mood in Obsessive-Compulsive Disorder: Preliminary Results

Abstract

The results suggest that OC symptoms may not depend on the short-time availability of serotonin. As some critical cognitive functions improved following tryptophan depletion, there is no evidence from our study that neuropsychological impairment in OCD can be reduced to a lowered level of serotonin. Future studies are needed to further clarify these findings by use of larger samples.