Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.7K citations

Experimental Psychopathology, Closed Arm Entries, Stress Hormone +11

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.8K citations

Hypothalamic Circuits, Hypothalamus-specific Mrna, Gastrointestinal Peptide Hormone +17

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

Christelle Peyron, Devin K. Tighe, Anthony N. van den Pol et al. · Journal of Neuroscience · 1998 · 3.5K citations · Full text

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

Neurophysiology, Physiology, Orexin Knockout Mice +8

Differential expression of orexin receptors 1 and 2 in the rat brain

Jacob Marcus, Carl Aschkenasi, Charlotte E. Lee et al. · The Journal of Comparative Neurology · 2001 · 1.6K citations

Synaptic Transmission, Neurotransmitter, Neurotransmission +22