Enantioselective Carbometalation of Cinnamyl Derivatives: New Access to Chiral Disubstituted Cyclopropanes— Configurational Stability of Benzylic Organozinc Halides

Abstract

Enantioselective addition of an alkyllithium compound across a double bond is achieved by the complexation of various primary or secondary organolithium compounds with (−)-sparteine [Eq. (a)]. This synthetic route is effective, simple, and may be useful for the synthesis of chiral disubstituted cyclopropanes.