Concepedia

Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

Elizabeth Claire Dees, Jeffrey R. Infante, Roger B. Cohen, Bert H. O’Neil, Suzanne F. Jones, Margaret von Mehren, Hadi Danaee, Yih Lee, Jeffrey Ecsedy, Mark Manfredi,

Cancer Chemotherapy and Pharmacology · 2010 · 75 citations · 21 references

DOI

Concepts

References

21

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer et al. · JNCI Journal of the National Cancer Institute · 2000 · 15.7K citations

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

Hongyi Zhou, Jian Kuang, Ling Zhong et al. · Nature Genetics · 1998 · 1.3K citations

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

James R. Bischoff · The EMBO Journal · 1998 · 1.2K citations · Full text

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Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

Claudia Crosio, Gian María Fimia, Romain Loury et al. · Molecular and Cellular Biology · 2002 · 665 citations · Full text

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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Mark Manfredi, Jeffrey Ecsedy, Kristan Meetze et al. · Proceedings of the National Academy of Sciences · 2007 · 413 citations · Full text

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