Ventricular Pre-Excitation and Cardiac Hypertrophy Mimicking Hypertrophic Cardiomyopathy in a Turkish Family with a Novel PRKAG2 Mutation

Abstract

Coexistence of unexplained ventricular hypertrophy and pre-excitation should prompt the diagnosis of PRKAG2 mutations and these patients should be referred for genetic analysis. The possible alteration of AMP-activated protein kinase activity due to genetic defects in PRKAG2 may serve as a template for developing more specific therapies in the treatment of patients with this mutation.