Cardiac troponin T Arg92Trp mutation and progression from hypertrophic to dilated cardiomyopathy

Abstract

The Arg92Trp substitution in the cardiac troponin T gene shows a high degree of penetrance, moderate hypertrophy, and early progression to dilated cardiomyopathy in Japanese patients. Early identification of individuals with this mutation may provide the opportunity to evaluate the efficacy of early therapeutic interventions.