Circulation · 1956 · 66 citations · 0 references
NeuroendocrinologyGynecologyFemale Reproductive FunctionHormonal FunctionsReproductive EndocrinologyMetabolic SyndromePublic HealthAtherosclerosisDyslipidemiaMenopause Hormone TherapyExpected Testicular DepressionEndocrine MechanismVascular BiologyEndocrinologyPharmacologyEstrogen TherapyOvarian HormoneCoronary AtherosclerosisCardiovascular DiseaseMedicineEndocrine Research
Middle-aged men with coronary atherosclerosis were studied before and at intervals after initiation of estrogen therapy over a 12-month period. Serum lipid studies during treatment revealed consistent increases in phospholipid and α-lipoprotein cholesterol and decreased β-/α-lipoprotein cholesterol ratios. Concomitant endocrine studies demonstrated the expected testicular depression without apparent detriment to thyroid or adrenal function.