Development of Pseudoboehmites for Nanosystems to Release Acyclovir

Abstract

The production of confined or adsorbed drugs in inorganic matrix has been increasing in areas like material science and pharmaceutical due to the possibility of the production of nanoadsorbed or encapsulated molecules with new properties like chemical stability, enhancing solubility and controlled release, what implies in new applications of materials. In the present work, a nanocomposite of a fine ceramic material, pseudoboehmite, and acyclovir, was prepared. Pseudoboehmite is based on a monohydroxide aluminum oxide produced from a synthetic route using ammonium hydroxide and aluminum nitrate or chloride as precursors in the sol-gel process. These systems had been characterized by the following techniques: MEV, TG/DSC, FTIR and UV-vis. The exposition of the drug to the pseudoboehmite at the dissolution equipment was at 37°C and 100rpm for 30 minutes. With the purpose to observe the interaction of the drug with the adsorbent, it was obtained the concentration of the drug in the solution, before and after the adsorption, using the UV-vis spectroscopy technique. The acyclovir has increased its solubility in an HCl 0,1M solution, when the weight ratio of Pseudoboehmite: Acyclovir 1:1 was used.