Concepedia

Increased Expression of Matrix Metalloproteinases in Mononuclear Blood Cells of Normal-Tension Glaucoma Patients

Olga Golubnitschaja, Kristina Yeghiazaryan, Rong Liu, Heike M nkemann, David Leppert, Hans H. Schild, Ivan O. Haefliger, Josef Flammer

Journal of Glaucoma · 2004 · 64 citations · 19 references

DOI

Abstract

A simultaneous upregulation of both MMP-9 and MT1-MMP gene expression and only slightly enhanced expression of TIMP-1 suggest an increased enzymatic matrix metalloproteinase activity delivered by mononuclear blood cells in these patients.

References

19

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

Ji Hoe Heo, Jacinta Lucero, Takeo Abumiya et al. · Journal of Cerebral Blood Flow & Metabolism · 1999 · 550 citations

Basal Lamina, Cerebrovascular Disease, Cerebral Vascular Regulation +17

Vascular dysregulation: a principal risk factor for glaucomatous damage?

Josef Flammer, Ivan O. Haefliger, Selim Orgül et al. · PubMed · 1999 · 260 citations

Hypertension, Ocular Disease, Glaucomatous Damage +16

Vascular Dysregulation

Josef Flammer, Ivan O. Haefliger, Selim Org l et al. · Journal of Glaucoma · 1999 · 194 citations

Hypertension, Ocular Disease, Ophthalmology +13

Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray

M. Rosario Hernandez, Olga A. Agapova, Ping Yang et al. · Glia · 2002 · 171 citations

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes

Olga A. Agapova, Cynthia S. Ricard, Mercedes Salvador‐Silva et al. · Glia · 2001 · 159 citations