Design and synthesis of orally active benzamide derivatives as potent serotonin 4 receptor agonist

The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons

Aline Dumuis, Mich�le Sebben, Jo�l Bockaert · Naunyn-Schmiedeberg s Archives of Pharmacology · 1989 · 290 citations

Neuropeptides, Biochemistry, Medicine +8

Potent new inhibitors of human renin

Michael Szelke, B Leckie, A. Hallett et al. · Nature · 1982 · 236 citations

Medicinal Chemistry, Medicine, Pharmacotherapy +5

Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig.

J.A.J. Schuurkes, Jan M. Van Nueten, P G Van Daele et al. · Journal of Pharmacology and Experimental Therapeutics · 1985 · 184 citations

[3H]-BRL 43694 (granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes

David R. Nelson, David R. Thomas · Biochemical Pharmacology · 1989 · 138 citations

Neurophysiology, Medicine, Functional Selectivity +10

Synthesis and biological activity of a ketomethylene analog of a tripeptide inhibitor of angiotensin converting enzyme

Ronald G. Almquist, Wan‐Ru Chao, Marie E. Ellis et al. · Journal of Medicinal Chemistry · 1980 · 95 citations