A Reduced Model Clarifies the Role of Feedback Loops and Time Delays in the Drosophila Circadian Oscillator

Exact stochastic simulation of coupled chemical reactions

Daniel T. Gillespie · The Journal of Physical Chemistry · 1977 · 10.4K citations

Engineering, Chemical Analysis, Altmetric Attention Score +19

Interacting Molecular Loops in the Mammalian Circadian Clock

Lauren P. Shearman, Sriram Sathyanarayanan, David R. Weaver et al. · Science · 2000 · 1.3K citations

Bmal1 Rhythms, Molecular Biology, Cryptochrome +17

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

Jeffrey L. Price, J. N. Blau, Adrian Rothenfluh et al. · Cell · 1998 · 845 citations · Full text

Biology, Period Protein Accumulation, Natural Sciences +7

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors <i>per</i> and <i>tim</i>

Thomas K. Darlington, Karen Wager‐Smith, M. Fernanda Ceriani et al. · Science · 1998 · 819 citations

Microarray Analysis and Organization of Circadian Gene Expression in Drosophila

Michael J. McDonald, Michael Rosbash · Cell · 2001 · 607 citations · Full text

Biology, Medicine, Genetics +9