Journal of Palliative Medicine · 2011 · 57 citations · 8 references
Parenteral hydromorphone has few neuroexcitatory symptoms until H3G accumulates past a neurotoxic threshold, such as might occur with increasing dose or duration, which, when exceeded, causes neuroexcitatory symptoms to manifest.
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Andrew Wright, Laurence E. Mather, Maree T. Smith · Life Sciences · 2001 · 133 citations
Opioid hyperexcitability: the application of alternate opioid therapy
Neil Macdonald, Linda Der, Sharon J. Allan et al. · Pain · 1993 · 113 citations