Concepedia

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

Anderson J. Ferreira, Vinayak Shenoy, Yoriko Yamazato, Srinivas Sriramula, Joseph Francis, Lihui Yuan, Ronald K. Castellano, David A. Ostrov, S. Paul Oh, Michael J. Katovich,

American Journal of Respiratory and Critical Care Medicine · 2009 · 247 citations · 17 references

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Abstract

These observations provide conceptual support that activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling PH.

References

17

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Inge Hamming, Wim Timens, MLC Bulthuis et al. · The Journal of Pathology · 2004 · 5.9K citations · Full text

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Angiotensin-converting enzyme 2 protects from severe acute lung failure

Yumiko Imai, Keiji Kuba, Shuan Rao et al. · Nature · 2005 · 2.5K citations · Full text

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Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

Tohru Minamino, Helen Christou, Chung-Ming Hsieh et al. · Proceedings of the National Academy of Sciences · 2001 · 364 citations · Full text

Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles

Lawrence S. Zisman, Rebecca S. Keller, Barbara A. Weaver et al. · Circulation · 2003 · 309 citations