Kinetics of growth and antibody production by a hybridoma cell line in a perfusion culture

A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH

William M. Miller, Harvey W. Blanch, C. R. Wilke · Biotechnology and Bioengineering · 1988 · 474 citations

Life Sciences, Biochemistry, Cell Biology +16

Advances in Animal Cell Biology and Technology for Bioprocesses

R.E. Spier · Vaccine · 1989 · 114 citations

Life Sciences, Biotechnology, Cell Biology +12

The loss of antibody productivity in continuous culture of hybridoma cells

Kelly K. Frame, Wei‐Shou Hu · Biotechnology and Bioengineering · 1990 · 112 citations

Life Sciences, Cell Biology, Immunology +13

Kinetic study of hybridoma cell growth in continuous culture. I. A model for non‐producing cells

Kelly K. Frame, Wei‐Shou Hu · Biotechnology and Bioengineering · 1991 · 75 citations

Life Sciences, Biotechnology, Cell Biology +17

High density culture of hybridoma cells using a perfusion culture vessel with an external centrifuge

Michiyuki Tokashiki, Takami Arai, Kimihiko Hamamoto et al. · Cytotechnology · 1990 · 68 citations

Engineering, Bioengineering, Cell Biology +13