THE EFFECTS OF DRUGS ON THE PRODUCTION AND RECOVERY PROCESSES OF THE STRESS ULCER

TLDR

Various procedures have been reported for studying the biosay of anti‑ulcer drugs. The study aimed to develop a new pharmacological assay to evaluate the curative activity of drugs on existing ulcers, addressing the lack of suitable methods for agents such as glutamine or methylmethionine sulfonium chloride. The authors used several rat ulcer models—including pylorus ligation, restraint, water immersion, and ulcerogenic agents—and administered drugs before ulcer induction to assess preventive effects. The paper reports curative effects of selected drugs on rat stress ulcers.

Abstract

Various procedures have been reported on the biossay of antiulcer drugs . Pylorus ligation of the rat (1-3), restraint of the rat (4, 5), water immersion of the restrained rat (7) and the application of ulcerogenic agents on various animals (8-11) were used for producing experimental ulcers. In these methods the drug had been administered to the animal before the ulcer production and the preventive effect on the ulcer producing processes was tested. Although some drugs such as glutamine or methylmethionine sulfonium chloride were recently introduced to promote the repair of the ulcer which had existed already, suitable methods are lacking for their pharmacological test, and so it was hoped to develop a new method for pharmacological assay of curative activity of the drugs on existing ulcers. In the present paper curative effects of some drugs on the stress ulcer of the rat are reported.