The Journal of Clinical Pharmacology · 1977 · 22 citations · 4 references
PharmacyPharmacokineticsPharmacologyDrug ClearanceHemodialysisRenal PharmacokineticsPharmacokinetics In Renal ImpairmentRenal ClearanceRenal Dose AdjustmentRenal Dose ModificationRenal Drug ClearanceRenal PharmacologyDose Adjustment During HemodialysisDrug Dosing During HemodialysisExtrarenal EliminationHemodialysis PharmacokineticsPharmacokinetics In Kidney DiseaseRate ConstantsSerum Half-lifeUrinary Recovery Of Drugs
The pharmacokinetic constants of cefazolin were determined comparatively in ten normal subjects, 12 patients with renal failure, and ten patients on repeated hemodialysis. Significant correlations could be established between the creatinine clearance values and the overall elimination rate constants (Ke), serum half-lives (T 1/2), plasmatic areas (Ftot), urinary recoveries (uo-6 hr), and renal clearances of the antibiotic (Cr). The pharmacokinetic changes produced by extrarenal removal were also studied. On the basis of the obtained results, a dosage schedule adjusted to renal status was proposed.
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