Breast Cancer: Induction of Differentiation by Embryonic Tissue

Jerome J. DeCosse, Carol Lynn Gossens, Joseph F. Kuzma, Brian R. Unsworth

Science · 1973 · 129 citations · 7 references

Abstract

A mouse mammary tumor, adenocarcinoma BW 10232, was maintained in vitro for 14 days, separated from embryonic mammary mesenchyme by a Millipore filter. Tubules developed in the tumor; deoxyibonucleic acid synthisis declined; and a presumptive acid mucopolysaccharide matrix, not evident in the controls, appeared.

References

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