Abnormal Bone Scan in an Adult With Osteopoikilosis

Abstract

Osteopoikilosis is rare, autosomal dominant bone disorder diagnosed by radiologic features. The findings include multiple small, circumscribed round areas of increased bone density distributed symmetrically in a periarticular location. The lesions cluster at the ends of long bones, around the acetabulum, and in the small bones of the hands and feet. Normal Tc-99m MDP uptake in osteopoikilosis on a bone scan may be used as a marker in distinguishing it from osteoblastic bone metastases, but there are a few previous reports of abnormal bone scan findings in osteopoikilosis among young patients. The authors describe a 40-year-old woman with osteopoikilosis characterized by classic radiologic findings and an abnormal bone scan.